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resources:pulm:ctd-ild [2026/10/27 19:07] – adminresources:pulm:ctd-ild [2026/10/27 20:05] (current) – admin
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   * [[https://doi.org/10.1093/rheumatology/keaf445 | ILD-RISC score]]   * [[https://doi.org/10.1093/rheumatology/keaf445 | ILD-RISC score]]
     * Outcome to predict: the presence of ILD on HRCT     * Outcome to predict: the presence of ILD on HRCT
 +    * score: a probability (0 to 1.0)
 +    * ILD-RISC score >= 0.3 had sensitivity 85.6% and specificity 53.6%
     * items:     * items:
       * <todo>age</todo>       * <todo>age</todo>
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       * <todo>FVC</todo>       * <todo>FVC</todo>
       * <todo>antibody (topo I: OR 2.38, PM/SCL: 2.56, RNAPIII: 1.41)</todo>       * <todo>antibody (topo I: OR 2.38, PM/SCL: 2.56, RNAPIII: 1.41)</todo>
 +
 +====== IIM-ILD ======
 +
 +===== FLAIR model =====
 +
 +  * [[https://doi.org/10.1016/j.chest.2020.04.057 | article]]
 +    * bottom line: MDA5 is bad, high inflammatory markers are bad, l
 +
 +^item^categorical_value^score^
 +| ferritin | >= 636 ng/mL | TRUE: 2, FALSE: 0|
 +| LDH | >= 355 U/L | TRUE: 2, FALSE: 0|
 +| anti-MDA5 antibody | >= 636 ng/mL | negative, 0; +, 2; ++, 3; +++, 4|
 +| high-resolution CT imaging score (as described by https://doi.org/10.1164/rccm.2106157)| >= 133 | TRUE: 3, FALSE: 0 |
 +
 +  * Scoring
 +    * low, 0 to 4
 +    * medium, 5 to 9
 +    * high, 10 to 13
 +
 +===== CROSS model =====
 +
 +^boolean parameter^ $\beta$ coefficient ^ score ^
 +| CRP abnormal | 0.754 | 1 |
 +| Anti-Ro52 positivity | 1.505 | 2 |
 +| male sex | 0.624 | 1 |
 +| disease duration <3 months | 1.291 | 2 |
 +
 +^ risk strata ^ qualifying scores ^
 +| moderate | 0-2 |
 +| high | 3-4 |
 +| very high | 5-6 |
 +
 +===== RRP model =====
 +
 +^boolean parameter^score if TRUE^
 +| fever | 5|
 +| periungual erythema | 6|
 +| elevated CRP | 5 |
 +| anti-MDA5 antibody | 8 |
 +| anti-Ro-52 antibody | 6 |
 +
 +
 +^ risk strata ^ qualifying scores ^
 +| moderate | 0-9 |
 +| high | 10-19 |
 +| very high | 20-30 |
resources/pulm/ctd-ild.1793128044.txt.gz · Last modified: by admin