===== Ideas ===== * Airway * [[https://doi.org/10.1001/jama.2024.0762 | Hyperangulated VL vs Standard DL in Surgical Patients]] * **Finding**: First-pass intubation failure: hyperangulated VL 1.7% vs DL 7.6% * **Significance**: More evidence VL is better as first-line? * [[https://doi.org/10.1111/anae.15985 | Mac Geometry VL vs Mac DL]] * **Finding:** VL had better first-pass success than DL * CARDS * [[https://doi.org/10.1016/j.resuscitation.2024.110360 | IV vs IO for OHCA]] * Finding: IV assoc with better survival and neuro fav outcomes * [[https://doi.org/10.1056/NEJMoa2307983 | MINT: Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia]] * **Finding**: In patients with acute myocardial infarction and anemia, a liberal transfusion strategy did not significantly reduce the risk of recurrent myocardial infarction or death at 30 days. * CCM * [[https://doi.org/10.1056/NEJMoa2404245 | Pantoprazole for MV GI bleed ppx]] * **Finding**: reduces GIB, no mortality benefit * [[https://doi.org/10.1097/CCM.0000000000006376 | Calcium for hyperK]] * **Finding**: not via membrane stabilization * MCS * [[https://doi.org/10.1056/NEJMoa2312572 | DANGER-SHOCK]] * **Finding**: Impella CP reduces mortality * **Significance**: First trial to show mortality benefit from MCS * PULM * [[ https://www.nejm.org/doi/full/10.1056/NEJMoa2406673 | Depemokimab]] * [[https://www.nejm.org/doi/full/10.1056/NEJMoa2409712 | Inebilizumab for Treatment of IgG4-Related Disease]] * GI * [[https://doi.org/10.1097/HEP.0000000000000817 | Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis]] * **Finding**: in Child-Pugh B or C with UGIB, TXA improves bleeding control vs placebo * Trauma * [[https://doi.org/10.1001/jama.2023.20850 | UK-REBOA]] * **Finding**: In trauma patients with exsanguinating hemorrhage, a strategy of REBOA and standard care in the emergency department does not reduce, and may increase, mortality compared with standard care alone.