Table of Contents

SSc-ILD
IIM-ILD

SSc-ILD

GAP score
ILD-RISC score
- Outcome to predict: the presence of ILD on HRCT
- score: a probability (0 to 1.0)
- ILD-RISC score >= 0.3 had sensitivity 85.6% and specificity 53.6%
- items:
  - age
  - ever had digital ulcers (OR 2.06)
  - DLCO
  - FVC
  - antibody (topo I: OR 2.38, PM/SCL: 2.56, RNAPIII: 1.41)

IIM-ILD

FLAIR model

article
- bottom line: MDA5 is bad, high inflammatory markers are bad, l

item	categorical_value	score
ferritin	>= 636 ng/mL	TRUE: 2, FALSE: 0
LDH	>= 355 U/L	TRUE: 2, FALSE: 0
anti-MDA5 antibody	>= 636 ng/mL	negative, 0; +, 2; ++, 3; +++, 4
high-resolution CT imaging score (as described by https://doi.org/10.1164/rccm.2106157)	>= 133	TRUE: 3, FALSE: 0

Scoring
- low, 0 to 4
- medium, 5 to 9
- high, 10 to 13

CROSS model

boolean parameter	$\beta$ coefficient	score
CRP abnormal	0.754	1
Anti-Ro52 positivity	1.505	2
male sex	0.624	1
disease duration <3 months	1.291	2

risk strata	qualifying scores
moderate	0-2
high	3-4
very high	5-6

RRP model

boolean parameter	score if TRUE
fever	5
periungual erythema	6
elevated CRP	5
anti-MDA5 antibody	8
anti-Ro-52 antibody	6

risk strata	qualifying scores
moderate	0-9
high	10-19
very high	20-30