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resources:pulm:ctd-ild
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Table of Contents
SSc-ILD
- GAP score
-
- Outcome to predict: the presence of ILD on HRCT
- score: a probability (0 to 1.0)
- ILD-RISC score >= 0.3 had sensitivity 85.6% and specificity 53.6%
- items:
- age
- ever had digital ulcers (OR 2.06)
- DLCO
- FVC
- antibody (topo I: OR 2.38, PM/SCL: 2.56, RNAPIII: 1.41)
IIM-ILD
FLAIR model
-
- bottom line: MDA5 is bad, high inflammatory markers are bad, l
| item | categorical_value | score |
|---|---|---|
| ferritin | >= 636 ng/mL | TRUE: 2, FALSE: 0 |
| LDH | >= 355 U/L | TRUE: 2, FALSE: 0 |
| anti-MDA5 antibody | >= 636 ng/mL | negative, 0; +, 2; ++, 3; +++, 4 |
| high-resolution CT imaging score (as described by https://doi.org/10.1164/rccm.2106157) | >= 133 | TRUE: 3, FALSE: 0 |
- Scoring
- low, 0 to 4
- medium, 5 to 9
- high, 10 to 13
CROSS model
| boolean parameter | $\beta$ coefficient | score |
|---|---|---|
| CRP abnormal | 0.754 | 1 |
| Anti-Ro52 positivity | 1.505 | 2 |
| male sex | 0.624 | 1 |
| disease duration <3 months | 1.291 | 2 |
| risk strata | qualifying scores |
|---|---|
| moderate | 0-2 |
| high | 3-4 |
| very high | 5-6 |
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